Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced...

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Detalles Bibliográficos
Autores principales: Treeck, O, Lattrich, C, Juhasz-Boess, I, Buchholz, S, Pfeiler, G, Ortmann, O
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570517/
https://www.ncbi.nlm.nih.gov/pubmed/18827813
http://dx.doi.org/10.1038/sj.bjc.6604692
Descripción
Sumario:Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERβ2, ERβ5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.

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