Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced...

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Autores principales: Treeck, O, Lattrich, C, Juhasz-Boess, I, Buchholz, S, Pfeiler, G, Ortmann, O
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570517/
https://www.ncbi.nlm.nih.gov/pubmed/18827813
http://dx.doi.org/10.1038/sj.bjc.6604692
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author Treeck, O
Lattrich, C
Juhasz-Boess, I
Buchholz, S
Pfeiler, G
Ortmann, O
author_facet Treeck, O
Lattrich, C
Juhasz-Boess, I
Buchholz, S
Pfeiler, G
Ortmann, O
author_sort Treeck, O
collection PubMed
description Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERβ2, ERβ5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.
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spelling pubmed-25705172009-10-21 Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells Treeck, O Lattrich, C Juhasz-Boess, I Buchholz, S Pfeiler, G Ortmann, O Br J Cancer Short Communication Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERβ2, ERβ5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine. Nature Publishing Group 2008-10-21 2008-09-30 /pmc/articles/PMC2570517/ /pubmed/18827813 http://dx.doi.org/10.1038/sj.bjc.6604692 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Treeck, O
Lattrich, C
Juhasz-Boess, I
Buchholz, S
Pfeiler, G
Ortmann, O
Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title_full Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title_fullStr Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title_full_unstemmed Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title_short Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
title_sort adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570517/
https://www.ncbi.nlm.nih.gov/pubmed/18827813
http://dx.doi.org/10.1038/sj.bjc.6604692
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