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The Role of Herpes Simplex Virus-1 Thymidine Kinase Alanine 168 in Substrate Specificity

Herpes simplex virus type 1 (HSV) thymidine kinase (TK) has been widely used in suicide gene therapy for the treatment of cancer due to its broad substrate specificity and the inability of the endogenous human TK to phosphorylate guanosine analogs such as ganciclovir (GCV). The basis of suicide gene...

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Detalles Bibliográficos
Autores principales:	Willmon, Candice L, Sussman, Django, Black, Margaret E
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Open 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570551/ https://www.ncbi.nlm.nih.gov/pubmed/18949076 http://dx.doi.org/10.2174/1874091X00802010060

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