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Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCF(β-TRCP) Ubiquitin Ligase in Hippocampal Neurons
The ubiquitin-proteasome pathway (UPP) regulates synaptic function, but little is known about specific UPP targets and mechanisms in mammalian synapses. We report here that the SCF(β-TRCP) complex, a multisubunit E3 ubiquitin ligase, targets the postsynaptic spine-associated Rap GTPase activating pr...
Autores principales: | Ang, Xiaolu L., Seeburg, Daniel P., Sheng, Morgan, Harper, J. Wade |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570879/ https://www.ncbi.nlm.nih.gov/pubmed/18723513 http://dx.doi.org/10.1074/jbc.M802475200 |
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