Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown tha...

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Autores principales: Bousquet, Marina, Quelen, Cathy, Rosati, Roberto, Mansat-De Mas, Véronique, La Starza, Roberta, Bastard, Christian, Lippert, Eric, Talmant, Pascaline, Lafage-Pochitaloff, Marina, Leroux, Dominique, Gervais, Carine, Viguié, Franck, Lai, Jean-Luc, Terre, Christine, Beverlo, Berna, Sambani, Costantina, Hagemeijer, Anne, Marynen, Peter, Delsol, Georges, Dastugue, Nicole, Mecucci, Cristina, Brousset, Pierre
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571925/
https://www.ncbi.nlm.nih.gov/pubmed/18936236
http://dx.doi.org/10.1084/jem.20080285
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author Bousquet, Marina
Quelen, Cathy
Rosati, Roberto
Mansat-De Mas, Véronique
La Starza, Roberta
Bastard, Christian
Lippert, Eric
Talmant, Pascaline
Lafage-Pochitaloff, Marina
Leroux, Dominique
Gervais, Carine
Viguié, Franck
Lai, Jean-Luc
Terre, Christine
Beverlo, Berna
Sambani, Costantina
Hagemeijer, Anne
Marynen, Peter
Delsol, Georges
Dastugue, Nicole
Mecucci, Cristina
Brousset, Pierre
author_facet Bousquet, Marina
Quelen, Cathy
Rosati, Roberto
Mansat-De Mas, Véronique
La Starza, Roberta
Bastard, Christian
Lippert, Eric
Talmant, Pascaline
Lafage-Pochitaloff, Marina
Leroux, Dominique
Gervais, Carine
Viguié, Franck
Lai, Jean-Luc
Terre, Christine
Beverlo, Berna
Sambani, Costantina
Hagemeijer, Anne
Marynen, Peter
Delsol, Georges
Dastugue, Nicole
Mecucci, Cristina
Brousset, Pierre
author_sort Bousquet, Marina
collection PubMed
description Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR-125b was able to interfere with primary human CD34(+) cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2;11) translocation define a new clinicopathological entity.
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spelling pubmed-25719252009-04-27 Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation Bousquet, Marina Quelen, Cathy Rosati, Roberto Mansat-De Mas, Véronique La Starza, Roberta Bastard, Christian Lippert, Eric Talmant, Pascaline Lafage-Pochitaloff, Marina Leroux, Dominique Gervais, Carine Viguié, Franck Lai, Jean-Luc Terre, Christine Beverlo, Berna Sambani, Costantina Hagemeijer, Anne Marynen, Peter Delsol, Georges Dastugue, Nicole Mecucci, Cristina Brousset, Pierre J Exp Med Brief Definitive Reports Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR-125b was able to interfere with primary human CD34(+) cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2;11) translocation define a new clinicopathological entity. The Rockefeller University Press 2008-10-27 /pmc/articles/PMC2571925/ /pubmed/18936236 http://dx.doi.org/10.1084/jem.20080285 Text en © 2008 Bousquet et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Brief Definitive Reports
Bousquet, Marina
Quelen, Cathy
Rosati, Roberto
Mansat-De Mas, Véronique
La Starza, Roberta
Bastard, Christian
Lippert, Eric
Talmant, Pascaline
Lafage-Pochitaloff, Marina
Leroux, Dominique
Gervais, Carine
Viguié, Franck
Lai, Jean-Luc
Terre, Christine
Beverlo, Berna
Sambani, Costantina
Hagemeijer, Anne
Marynen, Peter
Delsol, Georges
Dastugue, Nicole
Mecucci, Cristina
Brousset, Pierre
Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title_full Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title_fullStr Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title_full_unstemmed Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title_short Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
title_sort myeloid cell differentiation arrest by mir-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571925/
https://www.ncbi.nlm.nih.gov/pubmed/18936236
http://dx.doi.org/10.1084/jem.20080285
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