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Delta-like 4 is indispensable in thymic environment specific for T cell development

The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the absence of a thymic microenvironment. It is not cl...

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Detalles Bibliográficos
Autores principales:	Hozumi, Katsuto, Mailhos, Carolina, Negishi, Naoko, Hirano, Ken-ichi, Yahata, Takashi, Ando, Kiyoshi, Zuklys, Saulius, Holländer, Georg A., Shima, David T., Habu, Sonoko
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571926/ https://www.ncbi.nlm.nih.gov/pubmed/18824583 http://dx.doi.org/10.1084/jem.20080134

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