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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor–mediated signaling. Although the physiological ligands that interact with N1 expressed on thymic precursors are currently unknown, in vitro culture systems point to Delta-like 1 (DL1) and DL4 as prime candidates. Using DL1- and DL...

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Detalles Bibliográficos
Autores principales:	Koch, Ute, Fiorini, Emma, Benedito, Rui, Besseyrias, Valerie, Schuster-Gossler, Karin, Pierres, Michel, Manley, Nancy R., Duarte, Antonio, MacDonald, H. Robson, Radtke, Freddy
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571927/ https://www.ncbi.nlm.nih.gov/pubmed/18824585 http://dx.doi.org/10.1084/jem.20080829

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