Cargando…

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor–mediated signaling. Although the physiological ligands that interact with N1 expressed on thymic precursors are currently unknown, in vitro culture systems point to Delta-like 1 (DL1) and DL4 as prime candidates. Using DL1- and DL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koch, Ute, Fiorini, Emma, Benedito, Rui, Besseyrias, Valerie, Schuster-Gossler, Karin, Pierres, Michel, Manley, Nancy R., Duarte, Antonio, MacDonald, H. Robson, Radtke, Freddy
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571927/ https://www.ncbi.nlm.nih.gov/pubmed/18824585 http://dx.doi.org/10.1084/jem.20080829

Ejemplares similares

Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation
por: Besseyrias, Valerie, et al.
Publicado: (2007)

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells
por: Allman, David, et al.
Publicado: (2001)

Delta-like 4 is indispensable in thymic environment specific for T cell development
por: Hozumi, Katsuto, et al.
Publicado: (2008)

A third Notch in colorectal cancer progression and metastasis
por: Koch, Ute, et al.
Publicado: (2020)

Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
por: Lai, Anne Y., et al.
Publicado: (2006)

Identification of eosinophil lineage–committed progenitors in the murine bone marrow
por: Iwasaki, Hiromi, et al.
Publicado: (2005)

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
por: Liu, Dong, et al.
Publicado: (2020)

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major
por: Auderset, Floriane, et al.
Publicado: (2012)

Lack of Foxp3 function and expression in the thymic epithelium
por: Liston, Adrian, et al.
Publicado: (2007)

Commitment to the B Lymphoid Lineage Occurs before D(H)-J(H) Recombination
por: Allman, David, et al.
Publicado: (1999)

Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer–Associated Fibroblasts
por: Helms, Erin J., et al.
Publicado: (2022)

Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells
por: Dallas, Mari H., et al.
Publicado: (2005)

Thymic emigration revisited
por: McCaughtry, Tom M., et al.
Publicado: (2007)

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression
por: Male, Victoria, et al.
Publicado: (2014)

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
por: Garfin, Phillip M., et al.
Publicado: (2013)

CD8(−) DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS
por: Skokos, Dimitris, et al.
Publicado: (2007)

Asynchronous Coreceptor Downregulation after Positive Thymic Selection: Prolonged Maintenance of the Double Positive State in CD8 Lineage Differentiation Due to Sustained Biosynthesis of the CD4 Coreceptor
por: Barthlott, Thomas, et al.
Publicado: (1997)

Nonredundant roles of DIAPHs in primary ciliogenesis
por: Palander, Oliva, et al.
Publicado: (2021)

An Essential Role for Thymic Mesenchyme in Early T Cell Development
por: Suniara, Ravinder K., et al.
Publicado: (2000)

E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
por: Ikawa, Tomokatsu, et al.
Publicado: (2006)

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
por: Tveriakhina, Lena, et al.
Publicado: (2018)

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
por: Gray, Daniel, et al.
Publicado: (2007)

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
por: Koble, Christian, et al.
Publicado: (2009)

Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo
por: Schuster-Gossler, Karin, et al.
Publicado: (2021)

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus
por: Wilson, Anne, et al.
Publicado: (2001)

Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development
por: Schuster-Gossler, Karin, et al.
Publicado: (2009)

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation
por: Kenins, Linda, et al.
Publicado: (2008)

SPECIFIC HETEROLOGOUS ENHANCEMENT OF IMMUNE RESPONSES : II. IMMUNOLOGICAL MEMORY CELLS OF THYMIC ORIGIN
por: Rubin, Arnold S., et al.
Publicado: (1972)

TCR-dependent differentiation of thymic Foxp3(+) cells is limited to small clonal sizes
por: Leung, Monica W.L., et al.
Publicado: (2009)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Pleiotropic and nonredundant effects of an auxin importer in Setaria and maize
por: Zhu, Chuanmei, et al.
Publicado: (2022)

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
por: Mohan, James F., et al.
Publicado: (2011)

The effects of thymic stromal lymphopoietin and IL-3 on human eosinophil–basophil lineage commitment: Relevance to atopic sensitization
por: Hui, Claudia C K, et al.
Publicado: (2014)

CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment
por: Hysenaj, Lisiena, et al.
Publicado: (2023)

Notch signaling is an important regulator of type 2 immunity
por: Tu, LiLi, et al.
Publicado: (2005)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo
por: Preuße, Kristina, et al.
Publicado: (2015)

PRODUCTION OF TL ANTIBODY BY MICE IMMUNIZED WITH TL(-) CELL POPULATIONS : A POSSIBLE ASSAY FOR THYMIC HORMONE
por: Komuro, Katsutoshi, et al.
Publicado: (1973)

miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation
por: Dong, Jiayi, et al.
Publicado: (2020)

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling
por: Velardi, Enrico, et al.
Publicado: (2014)

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
por: Nishikawa, Yumiko, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pgb886bmp7sdui14d1fkvmqkt7