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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical epithelial cells are vital for positive selection, but whether such cells can also promote negative sel...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571932/ https://www.ncbi.nlm.nih.gov/pubmed/18936237 http://dx.doi.org/10.1084/jem.20080866 |