Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so thei...

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Detalles Bibliográficos
Autores principales: Keating, Brendan J., Tischfield, Sam, Murray, Sarah S., Bhangale, Tushar, Price, Thomas S., Glessner, Joseph T., Galver, Luana, Barrett, Jeffrey C., Grant, Struan F. A., Farlow, Deborah N., Chandrupatla, Hareesh R., Hansen, Mark, Ajmal, Saad, Papanicolaou, George J., Guo, Yiran, Li, Mingyao, DerOhannessian, Stephanie, de Bakker, Paul I. W., Bailey, Swneke D., Montpetit, Alexandre, Edmondson, Andrew C., Taylor, Kent, Gai, Xiaowu, Wang, Susanna S., Fornage, Myriam, Shaikh, Tamim, Groop, Leif, Boehnke, Michael, Hall, Alistair S., Hattersley, Andrew T., Frackelton, Edward, Patterson, Nick, Chiang, Charleston W. K., Kim, Cecelia E., Fabsitz, Richard R., Ouwehand, Willem, Price, Alkes L., Munroe, Patricia, Caulfield, Mark, Drake, Thomas, Boerwinkle, Eric, Reich, David, Whitehead, A. Stephen, Cappola, Thomas P., Samani, Nilesh J., Lusis, A. Jake, Schadt, Eric, Wilson, James G., Koenig, Wolfgang, McCarthy, Mark I., Kathiresan, Sekar, Gabriel, Stacey B., Hakonarson, Hakon, Anand, Sonia S., Reilly, Muredach, Engert, James C., Nickerson, Deborah A., Rader, Daniel J., Hirschhorn, Joel N., FitzGerald, Garret A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571995/
https://www.ncbi.nlm.nih.gov/pubmed/18974833
http://dx.doi.org/10.1371/journal.pone.0003583

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