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The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572037/ https://www.ncbi.nlm.nih.gov/pubmed/18838009 http://dx.doi.org/10.1186/1471-2261-8-25 |
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author | Neubeck, Lis Redfern, Julie Briffa, Tom Bauman, Adrian Hare, David Freedman, SB |
author_facet | Neubeck, Lis Redfern, Julie Briffa, Tom Bauman, Adrian Hare, David Freedman, SB |
author_sort | Neubeck, Lis |
collection | PubMed |
description | BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites and whether ongoing reinforcement further improves risk factor modification. METHODS/DESIGN: Participants eligible for but not accessing standard cardiac rehabilitation will be randomly allocated to either a previously tested 3-month CHOICE program or a 30-month CHOICE program (CHOICE-plus). Both groups will participate in individualised risk factor modules of differing duration that involve choice, goal setting and telephone follow-up for three months. CHOICE-plus will also receive additional face-to-face and telephone reinforcement between three and 30 months. At one site we will recruit a randomised control group, receiving conventional care. Primary outcomes are lipid levels, blood pressure, physical activity levels and smoking rates. Secondary outcomes include readmission rates, death, the number of risk factors, other modifiable risk factors, quality of life and process evaluation measures over three years. DISCUSSION: We present the rationale and design of a multi-centre, replication study testing a modular approach for the secondary prevention of CHD following an ACS. TRIAL REGISTRATION: [Clinical Trial Registration Number, ACTRN12608000182392] |
format | Text |
id | pubmed-2572037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25720372008-10-24 The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol Neubeck, Lis Redfern, Julie Briffa, Tom Bauman, Adrian Hare, David Freedman, SB BMC Cardiovasc Disord Study Protocol BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites and whether ongoing reinforcement further improves risk factor modification. METHODS/DESIGN: Participants eligible for but not accessing standard cardiac rehabilitation will be randomly allocated to either a previously tested 3-month CHOICE program or a 30-month CHOICE program (CHOICE-plus). Both groups will participate in individualised risk factor modules of differing duration that involve choice, goal setting and telephone follow-up for three months. CHOICE-plus will also receive additional face-to-face and telephone reinforcement between three and 30 months. At one site we will recruit a randomised control group, receiving conventional care. Primary outcomes are lipid levels, blood pressure, physical activity levels and smoking rates. Secondary outcomes include readmission rates, death, the number of risk factors, other modifiable risk factors, quality of life and process evaluation measures over three years. DISCUSSION: We present the rationale and design of a multi-centre, replication study testing a modular approach for the secondary prevention of CHD following an ACS. TRIAL REGISTRATION: [Clinical Trial Registration Number, ACTRN12608000182392] BioMed Central 2008-10-06 /pmc/articles/PMC2572037/ /pubmed/18838009 http://dx.doi.org/10.1186/1471-2261-8-25 Text en Copyright © 2008 Neubeck et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study Protocol Neubeck, Lis Redfern, Julie Briffa, Tom Bauman, Adrian Hare, David Freedman, SB The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title | The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title_full | The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title_fullStr | The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title_full_unstemmed | The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title_short | The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol |
title_sort | choice (choice of health options in prevention of cardiovascular events) replication trial: study protocol |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572037/ https://www.ncbi.nlm.nih.gov/pubmed/18838009 http://dx.doi.org/10.1186/1471-2261-8-25 |
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