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The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol

BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites...

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Autores principales: Neubeck, Lis, Redfern, Julie, Briffa, Tom, Bauman, Adrian, Hare, David, Freedman, SB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572037/
https://www.ncbi.nlm.nih.gov/pubmed/18838009
http://dx.doi.org/10.1186/1471-2261-8-25
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author Neubeck, Lis
Redfern, Julie
Briffa, Tom
Bauman, Adrian
Hare, David
Freedman, SB
author_facet Neubeck, Lis
Redfern, Julie
Briffa, Tom
Bauman, Adrian
Hare, David
Freedman, SB
author_sort Neubeck, Lis
collection PubMed
description BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites and whether ongoing reinforcement further improves risk factor modification. METHODS/DESIGN: Participants eligible for but not accessing standard cardiac rehabilitation will be randomly allocated to either a previously tested 3-month CHOICE program or a 30-month CHOICE program (CHOICE-plus). Both groups will participate in individualised risk factor modules of differing duration that involve choice, goal setting and telephone follow-up for three months. CHOICE-plus will also receive additional face-to-face and telephone reinforcement between three and 30 months. At one site we will recruit a randomised control group, receiving conventional care. Primary outcomes are lipid levels, blood pressure, physical activity levels and smoking rates. Secondary outcomes include readmission rates, death, the number of risk factors, other modifiable risk factors, quality of life and process evaluation measures over three years. DISCUSSION: We present the rationale and design of a multi-centre, replication study testing a modular approach for the secondary prevention of CHD following an ACS. TRIAL REGISTRATION: [Clinical Trial Registration Number, ACTRN12608000182392]
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spelling pubmed-25720372008-10-24 The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol Neubeck, Lis Redfern, Julie Briffa, Tom Bauman, Adrian Hare, David Freedman, SB BMC Cardiovasc Disord Study Protocol BACKGROUND: Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine whether the previously proven CHOICE program can be replicated at multiple sites and whether ongoing reinforcement further improves risk factor modification. METHODS/DESIGN: Participants eligible for but not accessing standard cardiac rehabilitation will be randomly allocated to either a previously tested 3-month CHOICE program or a 30-month CHOICE program (CHOICE-plus). Both groups will participate in individualised risk factor modules of differing duration that involve choice, goal setting and telephone follow-up for three months. CHOICE-plus will also receive additional face-to-face and telephone reinforcement between three and 30 months. At one site we will recruit a randomised control group, receiving conventional care. Primary outcomes are lipid levels, blood pressure, physical activity levels and smoking rates. Secondary outcomes include readmission rates, death, the number of risk factors, other modifiable risk factors, quality of life and process evaluation measures over three years. DISCUSSION: We present the rationale and design of a multi-centre, replication study testing a modular approach for the secondary prevention of CHD following an ACS. TRIAL REGISTRATION: [Clinical Trial Registration Number, ACTRN12608000182392] BioMed Central 2008-10-06 /pmc/articles/PMC2572037/ /pubmed/18838009 http://dx.doi.org/10.1186/1471-2261-8-25 Text en Copyright © 2008 Neubeck et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Neubeck, Lis
Redfern, Julie
Briffa, Tom
Bauman, Adrian
Hare, David
Freedman, SB
The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title_full The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title_fullStr The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title_full_unstemmed The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title_short The CHOICE (Choice of Health Options In prevention of Cardiovascular Events) replication trial: study protocol
title_sort choice (choice of health options in prevention of cardiovascular events) replication trial: study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572037/
https://www.ncbi.nlm.nih.gov/pubmed/18838009
http://dx.doi.org/10.1186/1471-2261-8-25
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