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RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma
BACKGROUND: Epigenetic silencing of RAS association family 1A (RASSF1A) tumor suppressor gene occurs in various histological subtypes of renal cell carcinoma (RCC) but RASSF1A protein expression in clear cell RCC as well as a possible correlation with clinicopathological parameters of patients has n...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572051/ https://www.ncbi.nlm.nih.gov/pubmed/18822131 http://dx.doi.org/10.1186/1471-2490-8-12 |
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author | Tezval, Hossein Merseburger, Axel S Matuschek, Ira Machtens, Stefan Kuczyk, Markus A Serth, Jürgen |
author_facet | Tezval, Hossein Merseburger, Axel S Matuschek, Ira Machtens, Stefan Kuczyk, Markus A Serth, Jürgen |
author_sort | Tezval, Hossein |
collection | PubMed |
description | BACKGROUND: Epigenetic silencing of RAS association family 1A (RASSF1A) tumor suppressor gene occurs in various histological subtypes of renal cell carcinoma (RCC) but RASSF1A protein expression in clear cell RCC as well as a possible correlation with clinicopathological parameters of patients has not been analyzed at yet. METHODS: 318 primary clear cell carcinomas were analyzed using tissue microarray analysis and immunohistochemistry. Survival analysis was carried out for 187 patients considering a follow-up period of 2–240 month. RESULTS: Expression of RASSF1A was found to be significantly decreased in tumoral cells when compared to normal tubular epithelial cells. RASSF1A immunopositivity was significantly associated with pT stage, group stage and histological grade of tumors and showed a tendency for impaired survival in Kaplan-Meier analysis. CONCLUSION: While most tumors demonstrate a loss of RASSF1A protein, a subset of tumors was identified to exhibit substantial RASSF1A protein expression and show increased tumor progression. Thus RCC tumorigenesis without depletion of RASSF1A may be associated with an adverse clinical outcome. |
format | Text |
id | pubmed-2572051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25720512008-10-24 RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma Tezval, Hossein Merseburger, Axel S Matuschek, Ira Machtens, Stefan Kuczyk, Markus A Serth, Jürgen BMC Urol Research Article BACKGROUND: Epigenetic silencing of RAS association family 1A (RASSF1A) tumor suppressor gene occurs in various histological subtypes of renal cell carcinoma (RCC) but RASSF1A protein expression in clear cell RCC as well as a possible correlation with clinicopathological parameters of patients has not been analyzed at yet. METHODS: 318 primary clear cell carcinomas were analyzed using tissue microarray analysis and immunohistochemistry. Survival analysis was carried out for 187 patients considering a follow-up period of 2–240 month. RESULTS: Expression of RASSF1A was found to be significantly decreased in tumoral cells when compared to normal tubular epithelial cells. RASSF1A immunopositivity was significantly associated with pT stage, group stage and histological grade of tumors and showed a tendency for impaired survival in Kaplan-Meier analysis. CONCLUSION: While most tumors demonstrate a loss of RASSF1A protein, a subset of tumors was identified to exhibit substantial RASSF1A protein expression and show increased tumor progression. Thus RCC tumorigenesis without depletion of RASSF1A may be associated with an adverse clinical outcome. BioMed Central 2008-09-26 /pmc/articles/PMC2572051/ /pubmed/18822131 http://dx.doi.org/10.1186/1471-2490-8-12 Text en Copyright © 2008 Tezval et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tezval, Hossein Merseburger, Axel S Matuschek, Ira Machtens, Stefan Kuczyk, Markus A Serth, Jürgen RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title | RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title_full | RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title_fullStr | RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title_full_unstemmed | RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title_short | RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
title_sort | rassf1a protein expression and correlation with clinicopathological parameters in renal cell carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572051/ https://www.ncbi.nlm.nih.gov/pubmed/18822131 http://dx.doi.org/10.1186/1471-2490-8-12 |
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