The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

Tail-anchored (TA) proteins, defined by the presence of a single C-terminal transmembrane domain (TMD), play critical roles throughout the secretory pathway and in mitochondria, yet the machinery responsible for their proper membrane insertion remains poorly characterized. Here we show that Get3, th...

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Detalles Bibliográficos
Autores principales: Schuldiner, Maya, Metz, Jutta, Schmid, Volker, Denic, Vladimir, Rakwalska, Magdalena, Schmitt, Hans Dieter, Schwappach, Blanche, Weissman, Jonathan S.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572727/
https://www.ncbi.nlm.nih.gov/pubmed/18724936
http://dx.doi.org/10.1016/j.cell.2008.06.025

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