A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa

Several large DNA viruses encode Bcl-2 protein homologues involved in the regulation of the cellular apoptosis cascade. This regulation often involves the interaction of these viral proteins with diverse cellular Bcl-2 family members. We have identified the specific interactions of A179L, an African...

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Detalles Bibliográficos
Autores principales: Galindo, Inmaculada, Hernaez, Bruno, Díaz-Gil, Gema, Escribano, Jose M., Alonso, Covadonga
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572728/
https://www.ncbi.nlm.nih.gov/pubmed/18329683
http://dx.doi.org/10.1016/j.virol.2008.01.050

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