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Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain

Several isoforms of phospholipase C (PLC) are regulated through interactions with Ras superfamily GTPases, including Rac proteins. Interestingly, of two closely related PLCγ isoforms, only PLCγ(2) has previously been shown to be activated by Rac. Here, we explore the molecular basis of this interact...

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Detalles Bibliográficos
Autores principales:	Walliser, Claudia, Retlich, Michael, Harris, Richard, Everett, Katy L., Josephs, Michelle B., Vatter, Petra, Esposito, Diego, Driscoll, Paul C., Katan, Matilda, Gierschik, Peter, Bunney, Tom D.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573054/ https://www.ncbi.nlm.nih.gov/pubmed/18728011 http://dx.doi.org/10.1074/jbc.M803316200

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