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Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up

BACKGROUND: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation. The purpose of this study was to investigate the impact of obesity on incide...

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Autores principales: Grotle, Margreth, Hagen, Kare B, Natvig, Bard, Dahl, Fredrik A, Kvien, Tore K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573886/
https://www.ncbi.nlm.nih.gov/pubmed/18831740
http://dx.doi.org/10.1186/1471-2474-9-132
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author Grotle, Margreth
Hagen, Kare B
Natvig, Bard
Dahl, Fredrik A
Kvien, Tore K
author_facet Grotle, Margreth
Hagen, Kare B
Natvig, Bard
Dahl, Fredrik A
Kvien, Tore K
author_sort Grotle, Margreth
collection PubMed
description BACKGROUND: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation. The purpose of this study was to investigate the impact of obesity on incident osteoarthritis (OA) in hip, knee, and hand in a general population followed in 10 years. METHODS: A total of 1854 people aged 24–76 years in 1994 participated in a Norwegian study on musculoskeletal pain in both 1994 and 2004. Participants with OA or rheumatoid arthritis in 1994 and those above 74 years in 1994 were excluded, leaving n = 1675 for the analyses. The main outcome measure was OA diagnosis at follow-up based on self-report. Obesity was defined by a body mass index (BMI) of 30 and above. RESULTS: At 10-years follow-up the incidence rates were 5.8% (CI 4.3–7.3) for hip OA, 7.3% (CI 5.7–9.0) for knee OA, and 5.6% (CI 4.2–7.1) for hand OA. When adjusting for age, gender, work status and leisure time activities, a high BMI (> 30) was significantly associated with knee OA (OR 2.81; 95%CI 1.32–5.96), and a dose-response relationship was found for this association. Obesity was also significantly associated with hand OA (OR 2.59; 1.08–6.19), but not with hip OA (OR 1.11; 0.41–2.97). There was no statistically significant interaction effect between BMI and gender, age or any of the other confounding variables. CONCLUSION: A high BMI was significantly associated with knee OA and hand OA, but not with hip OA.
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spelling pubmed-25738862008-10-28 Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up Grotle, Margreth Hagen, Kare B Natvig, Bard Dahl, Fredrik A Kvien, Tore K BMC Musculoskelet Disord Research Article BACKGROUND: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation. The purpose of this study was to investigate the impact of obesity on incident osteoarthritis (OA) in hip, knee, and hand in a general population followed in 10 years. METHODS: A total of 1854 people aged 24–76 years in 1994 participated in a Norwegian study on musculoskeletal pain in both 1994 and 2004. Participants with OA or rheumatoid arthritis in 1994 and those above 74 years in 1994 were excluded, leaving n = 1675 for the analyses. The main outcome measure was OA diagnosis at follow-up based on self-report. Obesity was defined by a body mass index (BMI) of 30 and above. RESULTS: At 10-years follow-up the incidence rates were 5.8% (CI 4.3–7.3) for hip OA, 7.3% (CI 5.7–9.0) for knee OA, and 5.6% (CI 4.2–7.1) for hand OA. When adjusting for age, gender, work status and leisure time activities, a high BMI (> 30) was significantly associated with knee OA (OR 2.81; 95%CI 1.32–5.96), and a dose-response relationship was found for this association. Obesity was also significantly associated with hand OA (OR 2.59; 1.08–6.19), but not with hip OA (OR 1.11; 0.41–2.97). There was no statistically significant interaction effect between BMI and gender, age or any of the other confounding variables. CONCLUSION: A high BMI was significantly associated with knee OA and hand OA, but not with hip OA. BioMed Central 2008-10-02 /pmc/articles/PMC2573886/ /pubmed/18831740 http://dx.doi.org/10.1186/1471-2474-9-132 Text en Copyright © 2008 Grotle et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grotle, Margreth
Hagen, Kare B
Natvig, Bard
Dahl, Fredrik A
Kvien, Tore K
Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title_full Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title_fullStr Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title_full_unstemmed Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title_short Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
title_sort obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573886/
https://www.ncbi.nlm.nih.gov/pubmed/18831740
http://dx.doi.org/10.1186/1471-2474-9-132
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