Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

Mutations that decrease insulin-like growth factor (IGF) and growth hormone signaling limit body size and prolong lifespan in mice. In vertebrates, these somatotropic hormones are controlled by the neuroendocrine brain. Hormone-like regulations discovered in nematodes and flies suggest that IGF sign...

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Detalles Bibliográficos
Autores principales: Kappeler, Laurent, Filho, Carlos De Magalhaes, Dupont, Joëlle, Leneuve, Patricia, Cervera, Pascale, Périn, Laurence, Loudes, Catherine, Blaise, Annick, Klein, Rüdiger, Epelbaum, Jacques, Bouc, Yves Le, Holzenberger, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573928/
https://www.ncbi.nlm.nih.gov/pubmed/18959478
http://dx.doi.org/10.1371/journal.pbio.0060254

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