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Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb
On the basis of its primary circuit it has been postulated that the olfactory bulb (OB) is analogous to the retina in mammals. In retina, repeated exposure to the same visual stimulus results in a neural representation that remains relatively stable over time, even as the meaning of that stimulus to...
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573932/ https://www.ncbi.nlm.nih.gov/pubmed/18959481 http://dx.doi.org/10.1371/journal.pbio.0060258 |
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author | Doucette, Wilder Restrepo, Diego |
author_facet | Doucette, Wilder Restrepo, Diego |
author_sort | Doucette, Wilder |
collection | PubMed |
description | On the basis of its primary circuit it has been postulated that the olfactory bulb (OB) is analogous to the retina in mammals. In retina, repeated exposure to the same visual stimulus results in a neural representation that remains relatively stable over time, even as the meaning of that stimulus to the animal changes. Stability of stimulus representation at early stages of processing allows for unbiased interpretation of incoming stimuli by higher order cortical centers. The alternative is that early stimulus representation is shaped by previously derived meaning, which could allow more efficient sampling of odor space providing a simplified yet biased interpretation of incoming stimuli. This study helps place the olfactory system on this continuum of subjective versus objective early sensory representation. Here we show that odor responses of the output cells of the OB, mitral cells, change transiently during a go–no-go odor discrimination task. The response changes occur in a manner that increases the ability of the circuit to convey information necessary to discriminate among closely related odors. Remarkably, a switch between which of the two odors is rewarded causes mitral cells to switch the polarity of their divergent responses. Taken together these results redefine the function of the OB as a transiently modifiable (active) filter, shaping early odor representations in behaviorally meaningful ways. |
format | Text |
id | pubmed-2573932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-25739322008-10-28 Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb Doucette, Wilder Restrepo, Diego PLoS Biol Research Article On the basis of its primary circuit it has been postulated that the olfactory bulb (OB) is analogous to the retina in mammals. In retina, repeated exposure to the same visual stimulus results in a neural representation that remains relatively stable over time, even as the meaning of that stimulus to the animal changes. Stability of stimulus representation at early stages of processing allows for unbiased interpretation of incoming stimuli by higher order cortical centers. The alternative is that early stimulus representation is shaped by previously derived meaning, which could allow more efficient sampling of odor space providing a simplified yet biased interpretation of incoming stimuli. This study helps place the olfactory system on this continuum of subjective versus objective early sensory representation. Here we show that odor responses of the output cells of the OB, mitral cells, change transiently during a go–no-go odor discrimination task. The response changes occur in a manner that increases the ability of the circuit to convey information necessary to discriminate among closely related odors. Remarkably, a switch between which of the two odors is rewarded causes mitral cells to switch the polarity of their divergent responses. Taken together these results redefine the function of the OB as a transiently modifiable (active) filter, shaping early odor representations in behaviorally meaningful ways. Public Library of Science 2008-10 2008-10-28 /pmc/articles/PMC2573932/ /pubmed/18959481 http://dx.doi.org/10.1371/journal.pbio.0060258 Text en © 2008 Doucette and Restrepo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Doucette, Wilder Restrepo, Diego Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title | Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title_full | Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title_fullStr | Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title_full_unstemmed | Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title_short | Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb |
title_sort | profound context-dependent plasticity of mitral cell responses in olfactory bulb |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573932/ https://www.ncbi.nlm.nih.gov/pubmed/18959481 http://dx.doi.org/10.1371/journal.pbio.0060258 |
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