CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination

At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the instability process remain undefined. Genomic fragmen...

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Detalles Bibliográficos
Autores principales: Libby, Randell T., Hagerman, Katharine A., Pineda, Victor V., Lau, Rachel, Cho, Diane H., Baccam, Sandy L., Axford, Michelle M., Cleary, John D., Moore, James M., Sopher, Bryce L., Tapscott, Stephen J., Filippova, Galina N., Pearson, Christopher E., La Spada, Albert R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573955/
https://www.ncbi.nlm.nih.gov/pubmed/19008940
http://dx.doi.org/10.1371/journal.pgen.1000257

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