Cargando…
Male-Specific Association between a γ-Secretase Polymorphism and Premature Coronary Atherosclerosis
BACKGROUND: Atherosclerosis is a common multifactorial disease resulting from an interaction between susceptibility genes and environmental factors. The causative genes that contribute to atherosclerosis are elusive. Based on recent findings with a Wistar rat model, we speculated that the γ-secretas...
Autores principales: | van Loo, Karen M. J., Dejaegere, Tim, van Zweeden, Martine, van Schijndel, Jessica E., Wijmenga, Cisca, Trip, Mieke D., Martens, Gerard J. M. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573958/ https://www.ncbi.nlm.nih.gov/pubmed/18987747 http://dx.doi.org/10.1371/journal.pone.0003662 |
Ejemplares similares
-
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010) -
Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010) -
γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022) -
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020) -
γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)