Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report

Hepatocellular carcinoma is rare, but increasing in prevalence in the United States. Recent studies have shown that sorafenib, a multikinase inhibitor, can reduce tumor progression in patients with this cancer. However, complete remission has not been observed. We report a case of a 78-year old pati...

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Detalles Bibliográficos
Autores principales: So, Brian J, Bekaii-Saab, Tanios, Bloomston, Mark A, Patel, Tushar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575202/
https://www.ncbi.nlm.nih.gov/pubmed/18928548
http://dx.doi.org/10.1186/1756-8722-1-18
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author So, Brian J
Bekaii-Saab, Tanios
Bloomston, Mark A
Patel, Tushar
author_facet So, Brian J
Bekaii-Saab, Tanios
Bloomston, Mark A
Patel, Tushar
author_sort So, Brian J
collection PubMed
description Hepatocellular carcinoma is rare, but increasing in prevalence in the United States. Recent studies have shown that sorafenib, a multikinase inhibitor, can reduce tumor progression in patients with this cancer. However, complete remission has not been observed. We report a case of a 78-year old patient with unresectable metastatic hepatocellular carcinoma who had a rapid and complete clinical response following therapy with sorafenib for six months. No evidence of disease recurrence has been noted for 6 months after discontinuation of therapy.
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spelling pubmed-25752022008-10-30 Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report So, Brian J Bekaii-Saab, Tanios Bloomston, Mark A Patel, Tushar J Hematol Oncol Case Report Hepatocellular carcinoma is rare, but increasing in prevalence in the United States. Recent studies have shown that sorafenib, a multikinase inhibitor, can reduce tumor progression in patients with this cancer. However, complete remission has not been observed. We report a case of a 78-year old patient with unresectable metastatic hepatocellular carcinoma who had a rapid and complete clinical response following therapy with sorafenib for six months. No evidence of disease recurrence has been noted for 6 months after discontinuation of therapy. BioMed Central 2008-10-17 /pmc/articles/PMC2575202/ /pubmed/18928548 http://dx.doi.org/10.1186/1756-8722-1-18 Text en Copyright © 2008 So et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
So, Brian J
Bekaii-Saab, Tanios
Bloomston, Mark A
Patel, Tushar
Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title_full Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title_fullStr Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title_full_unstemmed Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title_short Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report
title_sort complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575202/
https://www.ncbi.nlm.nih.gov/pubmed/18928548
http://dx.doi.org/10.1186/1756-8722-1-18
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AT pateltushar completeclinicalresponseofmetastatichepatocellularcarcinomatosorafenibinapatientwithhemochromatosisacasereport

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