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Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Aβ-induced degeneration and synaptic dysfunction. Th...

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Detalles Bibliográficos
Autores principales:	Yang, Tao, Knowles, Juliet K., Lu, Qun, Zhang, Hong, Arancio, Ottavio, Moore, Laura A., Chang, Timothy, Wang, Qian, Andreasson, Katrin, Rajadas, Jayakumar, Fuller, Gerald G., Xie, Youmei, Massa, Stephen M., Longo, Frank M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575383/ https://www.ncbi.nlm.nih.gov/pubmed/18978948 http://dx.doi.org/10.1371/journal.pone.0003604

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