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Breast cancer stem cells: implications for therapy of breast cancer
The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a m...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575525/ https://www.ncbi.nlm.nih.gov/pubmed/18671830 http://dx.doi.org/10.1186/bcr2111 |
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author | Morrison, Brian J Schmidt, Chris W Lakhani, Sunil R Reynolds, Brent A Lopez, J Alejandro |
author_facet | Morrison, Brian J Schmidt, Chris W Lakhani, Sunil R Reynolds, Brent A Lopez, J Alejandro |
author_sort | Morrison, Brian J |
collection | PubMed |
description | The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells. |
format | Text |
id | pubmed-2575525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25755252008-10-30 Breast cancer stem cells: implications for therapy of breast cancer Morrison, Brian J Schmidt, Chris W Lakhani, Sunil R Reynolds, Brent A Lopez, J Alejandro Breast Cancer Res Review The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells. BioMed Central 2008 2008-07-22 /pmc/articles/PMC2575525/ /pubmed/18671830 http://dx.doi.org/10.1186/bcr2111 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Review Morrison, Brian J Schmidt, Chris W Lakhani, Sunil R Reynolds, Brent A Lopez, J Alejandro Breast cancer stem cells: implications for therapy of breast cancer |
title | Breast cancer stem cells: implications for therapy of breast cancer |
title_full | Breast cancer stem cells: implications for therapy of breast cancer |
title_fullStr | Breast cancer stem cells: implications for therapy of breast cancer |
title_full_unstemmed | Breast cancer stem cells: implications for therapy of breast cancer |
title_short | Breast cancer stem cells: implications for therapy of breast cancer |
title_sort | breast cancer stem cells: implications for therapy of breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575525/ https://www.ncbi.nlm.nih.gov/pubmed/18671830 http://dx.doi.org/10.1186/bcr2111 |
work_keys_str_mv | AT morrisonbrianj breastcancerstemcellsimplicationsfortherapyofbreastcancer AT schmidtchrisw breastcancerstemcellsimplicationsfortherapyofbreastcancer AT lakhanisunilr breastcancerstemcellsimplicationsfortherapyofbreastcancer AT reynoldsbrenta breastcancerstemcellsimplicationsfortherapyofbreastcancer AT lopezjalejandro breastcancerstemcellsimplicationsfortherapyofbreastcancer |