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Breast cancer stem cells: implications for therapy of breast cancer

The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a m...

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Detalles Bibliográficos
Autores principales: Morrison, Brian J, Schmidt, Chris W, Lakhani, Sunil R, Reynolds, Brent A, Lopez, J Alejandro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575525/
https://www.ncbi.nlm.nih.gov/pubmed/18671830
http://dx.doi.org/10.1186/bcr2111
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author Morrison, Brian J
Schmidt, Chris W
Lakhani, Sunil R
Reynolds, Brent A
Lopez, J Alejandro
author_facet Morrison, Brian J
Schmidt, Chris W
Lakhani, Sunil R
Reynolds, Brent A
Lopez, J Alejandro
author_sort Morrison, Brian J
collection PubMed
description The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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spelling pubmed-25755252008-10-30 Breast cancer stem cells: implications for therapy of breast cancer Morrison, Brian J Schmidt, Chris W Lakhani, Sunil R Reynolds, Brent A Lopez, J Alejandro Breast Cancer Res Review The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells. BioMed Central 2008 2008-07-22 /pmc/articles/PMC2575525/ /pubmed/18671830 http://dx.doi.org/10.1186/bcr2111 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Review
Morrison, Brian J
Schmidt, Chris W
Lakhani, Sunil R
Reynolds, Brent A
Lopez, J Alejandro
Breast cancer stem cells: implications for therapy of breast cancer
title Breast cancer stem cells: implications for therapy of breast cancer
title_full Breast cancer stem cells: implications for therapy of breast cancer
title_fullStr Breast cancer stem cells: implications for therapy of breast cancer
title_full_unstemmed Breast cancer stem cells: implications for therapy of breast cancer
title_short Breast cancer stem cells: implications for therapy of breast cancer
title_sort breast cancer stem cells: implications for therapy of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575525/
https://www.ncbi.nlm.nih.gov/pubmed/18671830
http://dx.doi.org/10.1186/bcr2111
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AT reynoldsbrenta breastcancerstemcellsimplicationsfortherapyofbreastcancer
AT lopezjalejandro breastcancerstemcellsimplicationsfortherapyofbreastcancer