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The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

INTRODUCTION: Endocrine-dependent, estrogen receptor positive breast cancer cells proliferate in response to estrogens, synthesized by the cytochrome p450 aromatase enzyme. Letrozole is a potent nonsteroidal aromatase inhibitor that is registered for the treatment of postmenopausal women with advanc...

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Detalles Bibliográficos
Autores principales:	Lisztwan, Joanna, Pornon, Astrid, Chen, Bin, Chen, Shiuan, Evans, Dean B
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575527/ https://www.ncbi.nlm.nih.gov/pubmed/18611244 http://dx.doi.org/10.1186/bcr2113

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