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Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer
The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell gr...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575530/ https://www.ncbi.nlm.nih.gov/pubmed/18710598 http://dx.doi.org/10.1186/bcr2116 |
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author | Akkiprik, Mustafa Feng, Yumei Wang, Huamin Chen, Kexin Hu, Limei Sahin, Aysegul Krishnamurthy, Savitri Ozer, Ayse Hao, Xishan Zhang, Wei |
author_facet | Akkiprik, Mustafa Feng, Yumei Wang, Huamin Chen, Kexin Hu, Limei Sahin, Aysegul Krishnamurthy, Savitri Ozer, Ayse Hao, Xishan Zhang, Wei |
author_sort | Akkiprik, Mustafa |
collection | PubMed |
description | The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics. |
format | Text |
id | pubmed-2575530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25755302008-10-30 Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer Akkiprik, Mustafa Feng, Yumei Wang, Huamin Chen, Kexin Hu, Limei Sahin, Aysegul Krishnamurthy, Savitri Ozer, Ayse Hao, Xishan Zhang, Wei Breast Cancer Res Review The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics. BioMed Central 2008 2008-08-11 /pmc/articles/PMC2575530/ /pubmed/18710598 http://dx.doi.org/10.1186/bcr2116 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Review Akkiprik, Mustafa Feng, Yumei Wang, Huamin Chen, Kexin Hu, Limei Sahin, Aysegul Krishnamurthy, Savitri Ozer, Ayse Hao, Xishan Zhang, Wei Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title | Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title_full | Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title_fullStr | Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title_full_unstemmed | Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title_short | Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
title_sort | multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575530/ https://www.ncbi.nlm.nih.gov/pubmed/18710598 http://dx.doi.org/10.1186/bcr2116 |
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