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Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc

INTRODUCTION: The biological basis for the avascular state of the intervertebral disc is not well understood. Previous work has suggested that the presence of thrombospondin-1 (TSP-1), a matricellular protein, in the outer annulus reflects a role for this protein in conferring an avascular status to...

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Detalles Bibliográficos
Autores principales:	Gruber, Helen E, Bornstein, Paul, Sage, E Helene, Ingram, Jane A, Zinchenko, Natalia, Norton, H James, Hanley, Edward N
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575610/ https://www.ncbi.nlm.nih.gov/pubmed/18718009 http://dx.doi.org/10.1186/ar2483

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