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Formation of the blood–brain barrier: Wnt signaling seals the deal

Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in th...

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Detalles Bibliográficos
Autor principal: Polakis, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575777/
https://www.ncbi.nlm.nih.gov/pubmed/18955557
http://dx.doi.org/10.1083/jcb.200810040
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author Polakis, Paul
author_facet Polakis, Paul
author_sort Polakis, Paul
collection PubMed
description Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in the microvasculature. In this issue, Liebner et al. (Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. J. Cell Biol. 183: 409–417) report that Wnt signaling plays an active role in the development of the BBB by regulating expression of key protein constituents of the tight junction. Such mechanistic insight has implications for a variety of neuropathological states in which the BBB is breached.
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spelling pubmed-25757772009-05-03 Formation of the blood–brain barrier: Wnt signaling seals the deal Polakis, Paul J Cell Biol Reviews Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in the microvasculature. In this issue, Liebner et al. (Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. J. Cell Biol. 183: 409–417) report that Wnt signaling plays an active role in the development of the BBB by regulating expression of key protein constituents of the tight junction. Such mechanistic insight has implications for a variety of neuropathological states in which the BBB is breached. The Rockefeller University Press 2008-11-03 /pmc/articles/PMC2575777/ /pubmed/18955557 http://dx.doi.org/10.1083/jcb.200810040 Text en © 2008 Polakis This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Polakis, Paul
Formation of the blood–brain barrier: Wnt signaling seals the deal
title Formation of the blood–brain barrier: Wnt signaling seals the deal
title_full Formation of the blood–brain barrier: Wnt signaling seals the deal
title_fullStr Formation of the blood–brain barrier: Wnt signaling seals the deal
title_full_unstemmed Formation of the blood–brain barrier: Wnt signaling seals the deal
title_short Formation of the blood–brain barrier: Wnt signaling seals the deal
title_sort formation of the blood–brain barrier: wnt signaling seals the deal
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575777/
https://www.ncbi.nlm.nih.gov/pubmed/18955557
http://dx.doi.org/10.1083/jcb.200810040
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