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Formation of the blood–brain barrier: Wnt signaling seals the deal
Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in th...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575777/ https://www.ncbi.nlm.nih.gov/pubmed/18955557 http://dx.doi.org/10.1083/jcb.200810040 |
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author | Polakis, Paul |
author_facet | Polakis, Paul |
author_sort | Polakis, Paul |
collection | PubMed |
description | Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in the microvasculature. In this issue, Liebner et al. (Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. J. Cell Biol. 183: 409–417) report that Wnt signaling plays an active role in the development of the BBB by regulating expression of key protein constituents of the tight junction. Such mechanistic insight has implications for a variety of neuropathological states in which the BBB is breached. |
format | Text |
id | pubmed-2575777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25757772009-05-03 Formation of the blood–brain barrier: Wnt signaling seals the deal Polakis, Paul J Cell Biol Reviews Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in the microvasculature. In this issue, Liebner et al. (Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. J. Cell Biol. 183: 409–417) report that Wnt signaling plays an active role in the development of the BBB by regulating expression of key protein constituents of the tight junction. Such mechanistic insight has implications for a variety of neuropathological states in which the BBB is breached. The Rockefeller University Press 2008-11-03 /pmc/articles/PMC2575777/ /pubmed/18955557 http://dx.doi.org/10.1083/jcb.200810040 Text en © 2008 Polakis This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Polakis, Paul Formation of the blood–brain barrier: Wnt signaling seals the deal |
title | Formation of the blood–brain barrier: Wnt signaling seals the deal |
title_full | Formation of the blood–brain barrier: Wnt signaling seals the deal |
title_fullStr | Formation of the blood–brain barrier: Wnt signaling seals the deal |
title_full_unstemmed | Formation of the blood–brain barrier: Wnt signaling seals the deal |
title_short | Formation of the blood–brain barrier: Wnt signaling seals the deal |
title_sort | formation of the blood–brain barrier: wnt signaling seals the deal |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575777/ https://www.ncbi.nlm.nih.gov/pubmed/18955557 http://dx.doi.org/10.1083/jcb.200810040 |
work_keys_str_mv | AT polakispaul formationofthebloodbrainbarrierwntsignalingsealsthedeal |