Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms

Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology, Barr...

Descripción completa

Detalles Bibliográficos
Autores principales: Ley, Klaus, Zhang, Hong
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575778/
https://www.ncbi.nlm.nih.gov/pubmed/18981226
http://dx.doi.org/10.1083/jcb.200809173
_version_ 1782160350756470784
author Ley, Klaus
Zhang, Hong
author_facet Ley, Klaus
Zhang, Hong
author_sort Ley, Klaus
collection PubMed
description Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology, Barreiro et al. (Barreiro, O., M. Zamai, M. Yáñez-Mó, E. Tejera, P. López-Romero, P.N. Monk, E. Gratton, V.R. Caiolfa, and F. Sánchez-Madrid. 2008. J. Cell Biol. 183:527–542) show how the immunoglobulin superfamily adhesion molecules intercellular adhesion molecule (ICAM)–1 and vascular cell adhesion molecule (VCAM)–1 form nanoclusters with the tetraspanins CD9 and CD151 in a physiologically relevant system. Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts.
format Text
id pubmed-2575778
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-25757782009-05-03 Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms Ley, Klaus Zhang, Hong J Cell Biol Reviews Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology, Barreiro et al. (Barreiro, O., M. Zamai, M. Yáñez-Mó, E. Tejera, P. López-Romero, P.N. Monk, E. Gratton, V.R. Caiolfa, and F. Sánchez-Madrid. 2008. J. Cell Biol. 183:527–542) show how the immunoglobulin superfamily adhesion molecules intercellular adhesion molecule (ICAM)–1 and vascular cell adhesion molecule (VCAM)–1 form nanoclusters with the tetraspanins CD9 and CD151 in a physiologically relevant system. Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts. The Rockefeller University Press 2008-11-03 /pmc/articles/PMC2575778/ /pubmed/18981226 http://dx.doi.org/10.1083/jcb.200809173 Text en © 2008 Ley and Zhang This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Ley, Klaus
Zhang, Hong
Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title_full Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title_fullStr Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title_full_unstemmed Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title_short Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
title_sort dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575778/
https://www.ncbi.nlm.nih.gov/pubmed/18981226
http://dx.doi.org/10.1083/jcb.200809173
work_keys_str_mv AT leyklaus danceswithleukocyteshowtetraspaninenrichedmicrodomainsassembletoformendothelialadhesiveplatforms
AT zhanghong danceswithleukocyteshowtetraspaninenrichedmicrodomainsassembletoformendothelialadhesiveplatforms

Ejemplares similares