Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability

The Sonic Hedgehog (Shh) pathway plays important roles in embryogenesis, stem cell maintenance, tissue repair, and tumorigenesis. Haploinsufficiency of Patched-1, a gene that encodes a repressor of the Shh pathway, dysregulates the Shh pathway and increases genomic instability and the development of...

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Detalles Bibliográficos
Autores principales: Leonard, Jennifer M., Ye, Hong, Wetmore, Cynthia, Karnitz, Larry M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575780/
https://www.ncbi.nlm.nih.gov/pubmed/18955550
http://dx.doi.org/10.1083/jcb.200804042

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