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Segregation and activation of myosin IIB creates a rear in migrating cells
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, stable actin filament bundles and adhesions, which...
Autores principales: | Vicente-Manzanares, Miguel, Koach, Margaret A., Whitmore, Leanna, Lamers, Marcelo L., Horwitz, Alan F. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575793/ https://www.ncbi.nlm.nih.gov/pubmed/18955554 http://dx.doi.org/10.1083/jcb.200806030 |
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