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Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex

In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic–p...

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Autores principales: Giacobini, Paolo, Messina, Andrea, Morello, Francesca, Ferraris, Nicoletta, Corso, Simona, Penachioni, Junia, Giordano, Silvia, Tamagnone, Luca, Fasolo, Aldo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575794/
https://www.ncbi.nlm.nih.gov/pubmed/18981235
http://dx.doi.org/10.1083/jcb.200806160
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author Giacobini, Paolo
Messina, Andrea
Morello, Francesca
Ferraris, Nicoletta
Corso, Simona
Penachioni, Junia
Giordano, Silvia
Tamagnone, Luca
Fasolo, Aldo
author_facet Giacobini, Paolo
Messina, Andrea
Morello, Francesca
Ferraris, Nicoletta
Corso, Simona
Penachioni, Junia
Giordano, Silvia
Tamagnone, Luca
Fasolo, Aldo
author_sort Giacobini, Paolo
collection PubMed
description In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic–pituitary–gonadal axis. This migratory process is regulated by a wide range of guidance cues, which allow GnRH-1 cells to travel over long distances to reach their appropriate destinations. The Semaphorin4D (Sema4D) receptor, PlexinB1, is highly expressed in the developing olfactory placode, but its function in this context is still unknown. Here, we demonstrate that PlexinB1-deficient mice exhibit a migratory defect of GnRH-1 neurons, resulting in reduction of this cell population in the adult brain. Moreover, Sema4D promotes directional migration in GnRH-1 cells by coupling PlexinB1 with activation of the Met tyrosine kinase (hepatocyte growth factor receptor). This work identifies a function for PlexinB1 during brain development and provides evidence that Sema4D controls migration of GnRH-1 neurons.
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spelling pubmed-25757942009-05-03 Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex Giacobini, Paolo Messina, Andrea Morello, Francesca Ferraris, Nicoletta Corso, Simona Penachioni, Junia Giordano, Silvia Tamagnone, Luca Fasolo, Aldo J Cell Biol Research Articles In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic–pituitary–gonadal axis. This migratory process is regulated by a wide range of guidance cues, which allow GnRH-1 cells to travel over long distances to reach their appropriate destinations. The Semaphorin4D (Sema4D) receptor, PlexinB1, is highly expressed in the developing olfactory placode, but its function in this context is still unknown. Here, we demonstrate that PlexinB1-deficient mice exhibit a migratory defect of GnRH-1 neurons, resulting in reduction of this cell population in the adult brain. Moreover, Sema4D promotes directional migration in GnRH-1 cells by coupling PlexinB1 with activation of the Met tyrosine kinase (hepatocyte growth factor receptor). This work identifies a function for PlexinB1 during brain development and provides evidence that Sema4D controls migration of GnRH-1 neurons. The Rockefeller University Press 2008-11-03 /pmc/articles/PMC2575794/ /pubmed/18981235 http://dx.doi.org/10.1083/jcb.200806160 Text en © 2008 Giacobini et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Research Articles
Giacobini, Paolo
Messina, Andrea
Morello, Francesca
Ferraris, Nicoletta
Corso, Simona
Penachioni, Junia
Giordano, Silvia
Tamagnone, Luca
Fasolo, Aldo
Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title_full Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title_fullStr Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title_full_unstemmed Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title_short Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
title_sort semaphorin 4d regulates gonadotropin hormone–releasing hormone-1 neuronal migration through plexinb1–met complex
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575794/
https://www.ncbi.nlm.nih.gov/pubmed/18981235
http://dx.doi.org/10.1083/jcb.200806160
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