Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

BACKGROUND: LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ABCA1 and ABCG1 transporters, in macrophage and intestine. Anti-atherosclerotic...

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Detalles Bibliográficos
Autores principales: DiBlasio-Smith, Elizabeth A, Arai, Maya, Quinet, Elaine M, Evans, Mark J, Kornaga, Tad, Basso, Michael D, Chen, Liang, Feingold, Irene, Halpern, Anita R, Liu, Qiang-Yuan, Nambi, Ponnal, Savio, Dawn, Wang, Shuguang, Mounts, William M, Isler, Jennifer A, Slager, Anna M, Burczynski, Michael E, Dorner, Andrew J, LaVallie, Edward R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576083/
https://www.ncbi.nlm.nih.gov/pubmed/18925943
http://dx.doi.org/10.1186/1479-5876-6-59

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