Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein

Postsynaptic density (PSD)-93, a neuronal scaffolding protein, binds to and clusters N-methyl-D-aspartate receptor (NMDAR) subunits NR2A and NR2B at cellular membranes in vitro. However, the roles of PSD-93 in synaptic NR2A and NR2B targeting in the central nervous system and NMDAR-dependent physiol...

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Detalles Bibliográficos
Autores principales: Liaw, Wen-Jinn, Zhu, Xu-Guang, Yaster, Myron, Johns, Roger A, Gauda, Estelle B, Tao, Yuan-Xiang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576175/
https://www.ncbi.nlm.nih.gov/pubmed/18851757
http://dx.doi.org/10.1186/1744-8069-4-45

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