Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis

PURPOSE: The purpose of this study was to determine if downregulation of LIM kinase 1 (LIMK1) by genetic deletion or direct application of LIMK1-targeted siRNA could suppress TGF-β mediated ocular inflammation and fibrosis. METHODS: LIMK1 specific siRNAs designed from the human sequence were transfe...

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Detalles Bibliográficos
Autores principales: Gorovoy, Matvey, Koga, Takahisa, Shen, Xiang, Jia, Zhengping, Yue, Beatrice Y., Voyno-Yasenetskaya, Tatyana
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576479/
https://www.ncbi.nlm.nih.gov/pubmed/18978953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576479/
https://www.ncbi.nlm.nih.gov/pubmed/18978953

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