Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro

Inappropriate signalling through the EGFR and ErbB2/HER2 members of the epidermal growth factor family of receptor tyrosine kinases is well recognised as being causally linked to a variety of cancers. Consequently, monoclonal antibodies specific for these receptors have become increasingly important...

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Detalles Bibliográficos
Autores principales: Robinson, M K, Hodge, K M, Horak, E, Sundberg, Å L, Russeva, M, Shaller, C C, von Mehren, M, Shchaveleva, I, Simmons, H H, Marks, J D, Adams, G P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576487/
https://www.ncbi.nlm.nih.gov/pubmed/18841159
http://dx.doi.org/10.1038/sj.bjc.6604700

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