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Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Under hypoxic conditions, cells suppress energy-intensive mRNA translation by modulating the mammalian target of rapamycin (mTOR) and pancreatic eIF2α kinase (PERK) pathways. Much is known about hypoxic inhibition of mTOR activity; however, the cellular processes activating PERK remain unclear. Sinc...

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Detalles Bibliográficos
Autores principales:	Liu, Liping, Wise, David R., Diehl, J. Alan, Simon, M. Celeste
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576535/ https://www.ncbi.nlm.nih.gov/pubmed/18768473 http://dx.doi.org/10.1074/jbc.M805056200

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