The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome

BACKGROUND: Pseudoautosomal regions (PAR1 and PAR2) in eutherians retain homologous regions between the X and Y chromosomes that play a critical role in the obligatory X-Y crossover during male meiosis. Genes that reside in the PAR1 are exceptional in that they are rich in repetitive sequences and u...

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Autores principales: Levy, Michael A, Fernandes, Andrew D, Tremblay, Deanna C, Seah, Claudia, Bérubé, Nathalie G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577121/
https://www.ncbi.nlm.nih.gov/pubmed/18842153
http://dx.doi.org/10.1186/1471-2164-9-468
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author Levy, Michael A
Fernandes, Andrew D
Tremblay, Deanna C
Seah, Claudia
Bérubé, Nathalie G
author_facet Levy, Michael A
Fernandes, Andrew D
Tremblay, Deanna C
Seah, Claudia
Bérubé, Nathalie G
author_sort Levy, Michael A
collection PubMed
description BACKGROUND: Pseudoautosomal regions (PAR1 and PAR2) in eutherians retain homologous regions between the X and Y chromosomes that play a critical role in the obligatory X-Y crossover during male meiosis. Genes that reside in the PAR1 are exceptional in that they are rich in repetitive sequences and undergo a very high rate of recombination. Remarkably, murine PAR1 homologs have translocated to various autosomes, reflecting the complex recombination history during the evolution of the mammalian X chromosome. RESULTS: We now report that the SNF2-type chromatin remodeling protein ATRX controls the expression of eutherian ancestral PAR1 genes that have translocated to autosomes in the mouse. In addition, we have identified two potentially novel mouse PAR1 orthologs. CONCLUSION: We propose that the ancestral PAR1 genes share a common epigenetic environment that allows ATRX to control their expression.
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spelling pubmed-25771212008-11-01 The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome Levy, Michael A Fernandes, Andrew D Tremblay, Deanna C Seah, Claudia Bérubé, Nathalie G BMC Genomics Research Article BACKGROUND: Pseudoautosomal regions (PAR1 and PAR2) in eutherians retain homologous regions between the X and Y chromosomes that play a critical role in the obligatory X-Y crossover during male meiosis. Genes that reside in the PAR1 are exceptional in that they are rich in repetitive sequences and undergo a very high rate of recombination. Remarkably, murine PAR1 homologs have translocated to various autosomes, reflecting the complex recombination history during the evolution of the mammalian X chromosome. RESULTS: We now report that the SNF2-type chromatin remodeling protein ATRX controls the expression of eutherian ancestral PAR1 genes that have translocated to autosomes in the mouse. In addition, we have identified two potentially novel mouse PAR1 orthologs. CONCLUSION: We propose that the ancestral PAR1 genes share a common epigenetic environment that allows ATRX to control their expression. BioMed Central 2008-10-08 /pmc/articles/PMC2577121/ /pubmed/18842153 http://dx.doi.org/10.1186/1471-2164-9-468 Text en Copyright © 2008 Levy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Levy, Michael A
Fernandes, Andrew D
Tremblay, Deanna C
Seah, Claudia
Bérubé, Nathalie G
The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title_full The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title_fullStr The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title_full_unstemmed The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title_short The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
title_sort swi/snf protein atrx co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577121/
https://www.ncbi.nlm.nih.gov/pubmed/18842153
http://dx.doi.org/10.1186/1471-2164-9-468
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