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Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
In higher animal cells, the principal limitation of gene-targeting technology is the extremely low efficiency of targeted integration, which occurs three to four orders of magnitude less frequently than random integration. Assuming that random integration mechanistically involves non-homologous end-...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577324/ https://www.ncbi.nlm.nih.gov/pubmed/18835848 http://dx.doi.org/10.1093/nar/gkn649 |