Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes

Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) are found at high titers in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), a disease caused by AIRE gene mutations that lead to defects in thymic T-cell selection. Combining...

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Detalles Bibliográficos
Autores principales: Kisand, Kai, Link, Maire, Wolff, Anette S. B., Meager, Anthony, Tserel, Liina, Org, Tõnis, Murumägi, Astrid, Uibo, Raivo, Willcox, Nick, Trebušak Podkrajšek, Katarina, Battelino, Tadej, Lobell, Anna, Kämpe, Olle, Lima, Kari, Meloni, Antonella, Ergun-Longmire, Berrin, Maclaren, Noel K., Perheentupa, Jaakko, Krohn, Kai J. E., Scott, Hamish S., Husebye, Eystein S., Peterson, Pärt
Formato: Texto
Lenguaje:English
Publicado: American Society of Hematology 2008
Materias:
Chemokines, Cytokines, and Interleukins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577576/
https://www.ncbi.nlm.nih.gov/pubmed/18606876
http://dx.doi.org/10.1182/blood-2008-03-144634

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