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The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
BACKGROUND: 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3σ in the pathogenesis of vulva...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577690/ https://www.ncbi.nlm.nih.gov/pubmed/18950492 http://dx.doi.org/10.1186/1471-2407-8-308 |
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author | Wang, Zhihui Tropè, Claes G Suo, Zhenhe Trøen, Gunhild Yang, Guanrui Nesland, Jahn M Holm, Ruth |
author_facet | Wang, Zhihui Tropè, Claes G Suo, Zhenhe Trøen, Gunhild Yang, Guanrui Nesland, Jahn M Holm, Ruth |
author_sort | Wang, Zhihui |
collection | PubMed |
description | BACKGROUND: 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3σ in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3σ protein expression is still unknown. METHODS: We investigated the 14-3-3σ expression in a series of 302 vulvar squamous cell carcinomas using immunohistochemistry and its associations with clinicopathological factors and clinical outcome. RESULTS: In cytoplasm, nucleus and cytoplasm/nucleus of vulvar carcinomas high 14-3-3σ protein expression was found in 72%, 59% and 75% of the carcinomas, respectively, and low levels in 28%, 41% and 25% of the cases, respectively. High level of 14-3-3σ in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to large tumor diameter (p = 0.001, p = 0.002 and p = 0.001, respectively) and deep invasion (p = 0.01, p = 0.001 and p = 0.007, respectively). Variations of 14-3-3σ protein expression were not associated to disease-specific survival. CONCLUSION: Our results indicate that 14-3-3σ may be involved in the development of a subset of vulvar squamous cell carcinomas by down-regulation of 14-3-3σ protein. Neither cytoplasmic nor nuclear level of 14-3-3σ expression was associated with prognosis. |
format | Text |
id | pubmed-2577690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25776902008-11-04 The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas Wang, Zhihui Tropè, Claes G Suo, Zhenhe Trøen, Gunhild Yang, Guanrui Nesland, Jahn M Holm, Ruth BMC Cancer Research Article BACKGROUND: 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3σ in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3σ protein expression is still unknown. METHODS: We investigated the 14-3-3σ expression in a series of 302 vulvar squamous cell carcinomas using immunohistochemistry and its associations with clinicopathological factors and clinical outcome. RESULTS: In cytoplasm, nucleus and cytoplasm/nucleus of vulvar carcinomas high 14-3-3σ protein expression was found in 72%, 59% and 75% of the carcinomas, respectively, and low levels in 28%, 41% and 25% of the cases, respectively. High level of 14-3-3σ in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to large tumor diameter (p = 0.001, p = 0.002 and p = 0.001, respectively) and deep invasion (p = 0.01, p = 0.001 and p = 0.007, respectively). Variations of 14-3-3σ protein expression were not associated to disease-specific survival. CONCLUSION: Our results indicate that 14-3-3σ may be involved in the development of a subset of vulvar squamous cell carcinomas by down-regulation of 14-3-3σ protein. Neither cytoplasmic nor nuclear level of 14-3-3σ expression was associated with prognosis. BioMed Central 2008-10-24 /pmc/articles/PMC2577690/ /pubmed/18950492 http://dx.doi.org/10.1186/1471-2407-8-308 Text en Copyright © 2008 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Zhihui Tropè, Claes G Suo, Zhenhe Trøen, Gunhild Yang, Guanrui Nesland, Jahn M Holm, Ruth The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title_full | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title_fullStr | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title_full_unstemmed | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title_short | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
title_sort | clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577690/ https://www.ncbi.nlm.nih.gov/pubmed/18950492 http://dx.doi.org/10.1186/1471-2407-8-308 |
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