Cargando…
Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment
In this study the regional cerebral blood flow (rCBF) pattern of three Mild Cognitive Impairment (MCI) subtypes was measured with SPECT in 60 patients (nineteen with an amnestic deficit, sixteen with disexecutive deficits, and twenty five with mild multidomain deficits) and compared with that of 15...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577942/ https://www.ncbi.nlm.nih.gov/pubmed/19018314 http://dx.doi.org/10.2174/1874440000802010020 |
_version_ | 1782160518855786496 |
---|---|
author | Caffarra, Paolo Ghetti, Caterina Concari, Letizia Venneri, Annalena |
author_facet | Caffarra, Paolo Ghetti, Caterina Concari, Letizia Venneri, Annalena |
author_sort | Caffarra, Paolo |
collection | PubMed |
description | In this study the regional cerebral blood flow (rCBF) pattern of three Mild Cognitive Impairment (MCI) subtypes was measured with SPECT in 60 patients (nineteen with an amnestic deficit, sixteen with disexecutive deficits, and twenty five with mild multidomain deficits) and compared with that of 15 healthy matched older adults. The amnestic MCI subgroup showed significant hypoperfusion in the left hippocampus, parahippocampal gyrus and fronto-parieto-temporal areas. The disexecutive subgroup had significant hypoperfusion of the left superior, medial frontal and cingulate cortex. The multidomain subgroup had similar perfusion deficits to the amnestic subgroup, with an additional deficit in the left posterior cingulate gyrus. This study found differential patterns of hypoperfusion in MCI subtypes. Since all patients who progressed to dementia converted to probable Alzheimer’s disease, the different rCBF patterns most likely reflect the neuropathological heterogeneity at onset and differences in disease stage. |
format | Text |
id | pubmed-2577942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-25779422008-11-18 Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment Caffarra, Paolo Ghetti, Caterina Concari, Letizia Venneri, Annalena Open Neuroimag J Article In this study the regional cerebral blood flow (rCBF) pattern of three Mild Cognitive Impairment (MCI) subtypes was measured with SPECT in 60 patients (nineteen with an amnestic deficit, sixteen with disexecutive deficits, and twenty five with mild multidomain deficits) and compared with that of 15 healthy matched older adults. The amnestic MCI subgroup showed significant hypoperfusion in the left hippocampus, parahippocampal gyrus and fronto-parieto-temporal areas. The disexecutive subgroup had significant hypoperfusion of the left superior, medial frontal and cingulate cortex. The multidomain subgroup had similar perfusion deficits to the amnestic subgroup, with an additional deficit in the left posterior cingulate gyrus. This study found differential patterns of hypoperfusion in MCI subtypes. Since all patients who progressed to dementia converted to probable Alzheimer’s disease, the different rCBF patterns most likely reflect the neuropathological heterogeneity at onset and differences in disease stage. Bentham Open 2008-05-09 /pmc/articles/PMC2577942/ /pubmed/19018314 http://dx.doi.org/10.2174/1874440000802010020 Text en © Caffarra et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Caffarra, Paolo Ghetti, Caterina Concari, Letizia Venneri, Annalena Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title | Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title_full | Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title_fullStr | Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title_full_unstemmed | Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title_short | Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment |
title_sort | differential patterns of hypoperfusion in subtypes of mild cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577942/ https://www.ncbi.nlm.nih.gov/pubmed/19018314 http://dx.doi.org/10.2174/1874440000802010020 |
work_keys_str_mv | AT caffarrapaolo differentialpatternsofhypoperfusioninsubtypesofmildcognitiveimpairment AT ghetticaterina differentialpatternsofhypoperfusioninsubtypesofmildcognitiveimpairment AT concariletizia differentialpatternsofhypoperfusioninsubtypesofmildcognitiveimpairment AT venneriannalena differentialpatternsofhypoperfusioninsubtypesofmildcognitiveimpairment |