Cytotoxicity of TNT and its metabolites.

The production and storage of explosives has resulted in the environmental accumulation of 2,4,6-trinitrotoluene (TNT). The biotransformation products of the nitroaromatic compound TNT and metabolites in mammalian cells in culture and their cytotoxicity are studied. We report after our analysis by r...

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Detalles Bibliográficos
Autores principales: Banerjee, H. N., Verma, M., Hou, L. H., Ashraf, M., Dutta, S. K.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578962/
https://www.ncbi.nlm.nih.gov/pubmed/10691043
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author Banerjee, H. N.
Verma, M.
Hou, L. H.
Ashraf, M.
Dutta, S. K.
author_facet Banerjee, H. N.
Verma, M.
Hou, L. H.
Ashraf, M.
Dutta, S. K.
author_sort Banerjee, H. N.
collection PubMed
description The production and storage of explosives has resulted in the environmental accumulation of 2,4,6-trinitrotoluene (TNT). The biotransformation products of the nitroaromatic compound TNT and metabolites in mammalian cells in culture and their cytotoxicity are studied. We report after our analysis by reverse phase high performance liquid chromatography (HPLC) that the most prevalent biotransformation product of TNT in the NG108 neuroblastoma cells is primarily monoamino-dinitrotoluene (2Am-DNT). It causes toxic effects based on trypan blue exclusion and LDH-release colorimetric assays.
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spelling pubmed-25789622008-11-05 Cytotoxicity of TNT and its metabolites. Banerjee, H. N. Verma, M. Hou, L. H. Ashraf, M. Dutta, S. K. Yale J Biol Med Research Article The production and storage of explosives has resulted in the environmental accumulation of 2,4,6-trinitrotoluene (TNT). The biotransformation products of the nitroaromatic compound TNT and metabolites in mammalian cells in culture and their cytotoxicity are studied. We report after our analysis by reverse phase high performance liquid chromatography (HPLC) that the most prevalent biotransformation product of TNT in the NG108 neuroblastoma cells is primarily monoamino-dinitrotoluene (2Am-DNT). It causes toxic effects based on trypan blue exclusion and LDH-release colorimetric assays. Yale Journal of Biology and Medicine 1999 /pmc/articles/PMC2578962/ /pubmed/10691043 Text en
spellingShingle Research Article
Banerjee, H. N.
Verma, M.
Hou, L. H.
Ashraf, M.
Dutta, S. K.
Cytotoxicity of TNT and its metabolites.
title Cytotoxicity of TNT and its metabolites.
title_full Cytotoxicity of TNT and its metabolites.
title_fullStr Cytotoxicity of TNT and its metabolites.
title_full_unstemmed Cytotoxicity of TNT and its metabolites.
title_short Cytotoxicity of TNT and its metabolites.
title_sort cytotoxicity of tnt and its metabolites.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578962/
https://www.ncbi.nlm.nih.gov/pubmed/10691043
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AT vermam cytotoxicityoftntanditsmetabolites
AT houlh cytotoxicityoftntanditsmetabolites
AT ashrafm cytotoxicityoftntanditsmetabolites
AT duttask cytotoxicityoftntanditsmetabolites

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