Cargando…

The fate of released histamine: reception, response and termination.

Histamine released from ECL cells elicits responses from a variety of cellular targets in the vicinity. Three sets of receptors are involved (H1, H2 and H3). Receptor occupation is promptly transduced into cellular responses. The responses, in turn, are terminated by diverse mechanisms: enzymatic in...

Descripción completa

Detalles Bibliográficos
Autor principal: Rangachari, P. K.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578985/
https://www.ncbi.nlm.nih.gov/pubmed/10461350
_version_ 1782160549872664576
author Rangachari, P. K.
author_facet Rangachari, P. K.
author_sort Rangachari, P. K.
collection PubMed
description Histamine released from ECL cells elicits responses from a variety of cellular targets in the vicinity. Three sets of receptors are involved (H1, H2 and H3). Receptor occupation is promptly transduced into cellular responses. The responses, in turn, are terminated by diverse mechanisms: enzymatic inactivation, cellular uptake and desensitization at the receptor level. Under specific pathological conditions, histamine effects could be exaggerated by the presence of derivatives that may be of marginal relevance under physiological conditions.
format Text
id pubmed-2578985
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Yale Journal of Biology and Medicine
record_format MEDLINE/PubMed
spelling pubmed-25789852008-11-05 The fate of released histamine: reception, response and termination. Rangachari, P. K. Yale J Biol Med Research Article Histamine released from ECL cells elicits responses from a variety of cellular targets in the vicinity. Three sets of receptors are involved (H1, H2 and H3). Receptor occupation is promptly transduced into cellular responses. The responses, in turn, are terminated by diverse mechanisms: enzymatic inactivation, cellular uptake and desensitization at the receptor level. Under specific pathological conditions, histamine effects could be exaggerated by the presence of derivatives that may be of marginal relevance under physiological conditions. Yale Journal of Biology and Medicine 1998 /pmc/articles/PMC2578985/ /pubmed/10461350 Text en
spellingShingle Research Article
Rangachari, P. K.
The fate of released histamine: reception, response and termination.
title The fate of released histamine: reception, response and termination.
title_full The fate of released histamine: reception, response and termination.
title_fullStr The fate of released histamine: reception, response and termination.
title_full_unstemmed The fate of released histamine: reception, response and termination.
title_short The fate of released histamine: reception, response and termination.
title_sort fate of released histamine: reception, response and termination.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578985/
https://www.ncbi.nlm.nih.gov/pubmed/10461350
work_keys_str_mv AT rangacharipk thefateofreleasedhistaminereceptionresponseandtermination
AT rangacharipk fateofreleasedhistaminereceptionresponseandtermination