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Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence

BACKGROUND: Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing proteins. These two types of proteins have different...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaofan, Ma, Hong
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579438/
https://www.ncbi.nlm.nih.gov/pubmed/18950507
http://dx.doi.org/10.1186/1471-2148-8-294