HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

Neurologic disease caused by human immunodeficiency virus type 1 (HIV-1) is ultimately refractory to highly active antiretroviral therapy (HAART) because of failure of complete virus eradication in the central nervous system (CNS), and disruption of normal neural signaling events by virally induced...

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Detalles Bibliográficos
Autores principales: Norman, John P., Perry, Seth W., Reynolds, Holly M., Kiebala, Michelle, De Mesy Bentley, Karen L., Trejo, Margarita, Volsky, David J., Maggirwar, Sanjay B., Dewhurst, Stephen, Masliah, Eliezer, Gelbard, Harris A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579580/
https://www.ncbi.nlm.nih.gov/pubmed/19009018
http://dx.doi.org/10.1371/journal.pone.0003731

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