Sex-specific risk factor profile in oesophageal adenocarcinoma

A nationwide Swedish case–control study of 388 men and 63 women with adenocarcinoma of the oesophagus and gastro-oesophageal function and 676 men controls and 140 women investigated whether sex differences in aetiology contribute to male predominance. Compared with men, women seemed more vulnerable...

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Autores principales: Löfdahl, H E, Lu, Y, Lagergren, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579703/
https://www.ncbi.nlm.nih.gov/pubmed/18841152
http://dx.doi.org/10.1038/sj.bjc.6604701
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author Löfdahl, H E
Lu, Y
Lagergren, J
author_facet Löfdahl, H E
Lu, Y
Lagergren, J
author_sort Löfdahl, H E
collection PubMed
description A nationwide Swedish case–control study of 388 men and 63 women with adenocarcinoma of the oesophagus and gastro-oesophageal function and 676 men controls and 140 women investigated whether sex differences in aetiology contribute to male predominance. Compared with men, women seemed more vulnerable to reflux (odds ratio (OR)=4.6, 95% confidence interval (CI)=2.0–10.5 vs OR=3.4, 95% CI=2.5–4.6), obesity (OR=10.3, 95% CI=2.6–42.3 vs OR=5.4, 95% CI=2.6–10.8) and smoking (OR=5.3, 95% CI=2.0–14.1 vs OR=2.8, 95% CI=1.9–4.2), less harmed by low intake of fruit and vegetables (OR=0.9, 95% CI 0.3–2.4 vs OR=1.6, 95% CI=1.1–2.2) and less protected by Helicobacter pylori infection (OR=0.5, 95% CI=0.3–0.8 vs OR=1.6, 95% CI=0.5–5.4).
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spelling pubmed-25797032009-11-04 Sex-specific risk factor profile in oesophageal adenocarcinoma Löfdahl, H E Lu, Y Lagergren, J Br J Cancer Short Communication A nationwide Swedish case–control study of 388 men and 63 women with adenocarcinoma of the oesophagus and gastro-oesophageal function and 676 men controls and 140 women investigated whether sex differences in aetiology contribute to male predominance. Compared with men, women seemed more vulnerable to reflux (odds ratio (OR)=4.6, 95% confidence interval (CI)=2.0–10.5 vs OR=3.4, 95% CI=2.5–4.6), obesity (OR=10.3, 95% CI=2.6–42.3 vs OR=5.4, 95% CI=2.6–10.8) and smoking (OR=5.3, 95% CI=2.0–14.1 vs OR=2.8, 95% CI=1.9–4.2), less harmed by low intake of fruit and vegetables (OR=0.9, 95% CI 0.3–2.4 vs OR=1.6, 95% CI=1.1–2.2) and less protected by Helicobacter pylori infection (OR=0.5, 95% CI=0.3–0.8 vs OR=1.6, 95% CI=0.5–5.4). Nature Publishing Group 2008-11-04 2008-10-07 /pmc/articles/PMC2579703/ /pubmed/18841152 http://dx.doi.org/10.1038/sj.bjc.6604701 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Löfdahl, H E
Lu, Y
Lagergren, J
Sex-specific risk factor profile in oesophageal adenocarcinoma
title Sex-specific risk factor profile in oesophageal adenocarcinoma
title_full Sex-specific risk factor profile in oesophageal adenocarcinoma
title_fullStr Sex-specific risk factor profile in oesophageal adenocarcinoma
title_full_unstemmed Sex-specific risk factor profile in oesophageal adenocarcinoma
title_short Sex-specific risk factor profile in oesophageal adenocarcinoma
title_sort sex-specific risk factor profile in oesophageal adenocarcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579703/
https://www.ncbi.nlm.nih.gov/pubmed/18841152
http://dx.doi.org/10.1038/sj.bjc.6604701
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AT luy sexspecificriskfactorprofileinoesophagealadenocarcinoma
AT lagergrenj sexspecificriskfactorprofileinoesophagealadenocarcinoma

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