Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Paz, Beatriz, Daranas, Antonio H., Cruz, Patricia G., Franco, José M., Norte, Manuel, Fernández, José J.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579738/
https://www.ncbi.nlm.nih.gov/pubmed/19005581
http://dx.doi.org/10.3390/md20080024
_version_ 1782160590901346304
author Paz, Beatriz
Daranas, Antonio H.
Cruz, Patricia G.
Franco, José M.
Norte, Manuel
Fernández, José J.
author_facet Paz, Beatriz
Daranas, Antonio H.
Cruz, Patricia G.
Franco, José M.
Norte, Manuel
Fernández, José J.
author_sort Paz, Beatriz
collection PubMed
description Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS).
format Text
id pubmed-2579738
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-25797382008-11-12 Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection Paz, Beatriz Daranas, Antonio H. Cruz, Patricia G. Franco, José M. Norte, Manuel Fernández, José J. Mar Drugs Article Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS). Molecular Diversity Preservation International 2008-08-28 /pmc/articles/PMC2579738/ /pubmed/19005581 http://dx.doi.org/10.3390/md20080024 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
spellingShingle Article
Paz, Beatriz
Daranas, Antonio H.
Cruz, Patricia G.
Franco, José M.
Norte, Manuel
Fernández, José J.
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title_full Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title_fullStr Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title_full_unstemmed Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title_short Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
title_sort identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579738/
https://www.ncbi.nlm.nih.gov/pubmed/19005581
http://dx.doi.org/10.3390/md20080024
work_keys_str_mv AT pazbeatriz identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection
AT daranasantonioh identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection
AT cruzpatriciag identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection
AT francojosem identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection
AT nortemanuel identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection
AT fernandezjosej identificationof19epiokadaicacidanewdiarrheticshellfishpoisoningtoxinbyliquidchromatographywithmassspectrometrydetection

Ejemplares similares