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Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level

It has been speculated that human leukocyte antigen (HLA) alleles are associated with the outcome of hepatitis B virus (HBV) infection although the data obtained from various populations have shown some inconsistencies. A total of 464 HBV-infected Korean individuals (80 spontaneously recovered [SR]...

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Autores principales: Cho, Sung Won, Cheong, Jae Youn, Ju, Young Su, Oh, Do Hoon, Suh, Young Ju, Lee, Kyung Wha
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579996/
https://www.ncbi.nlm.nih.gov/pubmed/18955791
http://dx.doi.org/10.3346/jkms.2008.23.5.838
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author Cho, Sung Won
Cheong, Jae Youn
Ju, Young Su
Oh, Do Hoon
Suh, Young Ju
Lee, Kyung Wha
author_facet Cho, Sung Won
Cheong, Jae Youn
Ju, Young Su
Oh, Do Hoon
Suh, Young Ju
Lee, Kyung Wha
author_sort Cho, Sung Won
collection PubMed
description It has been speculated that human leukocyte antigen (HLA) alleles are associated with the outcome of hepatitis B virus (HBV) infection although the data obtained from various populations have shown some inconsistencies. A total of 464 HBV-infected Korean individuals (80 spontaneously recovered [SR] and 384 chronically infected [CI]) were selected to investigate the association of HLA class II alleles with the viral clearance and persistence. Our results showed that: 1) multiple HLA class II alleles and haplotypes were associated with viral clearance (DRB1*1302, DRB1*1502, DQB1*0302, DQB1*0609, and related-haplotypes) and persistence (DRB1*0701, DQB1*0301, and related-haplotypes); 2) DRB1*1302 and DQB1* 0609 were more strongly associated with viral clearance. And the association of DQB1*0609 (p(c)=0.0084; OR, 7.24) with vial clearance was much stronger than previously recognized, DRB1*1302 (p(c)=0.0038; OR, 4.34); and 3) linkage to a specific DPB1 allele in a haplotype strengthened the association with viral clearance, although DPB1 itself was not associated with the outcome. These results indicate the existence of multiple factors controlling viral clearance in the HLA class II gene region. Further extended investigation on the genetic factors related to the outcome of HBV infection will provide valuable insights into the understanding of the mechanisms involved.
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spelling pubmed-25799962008-11-07 Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level Cho, Sung Won Cheong, Jae Youn Ju, Young Su Oh, Do Hoon Suh, Young Ju Lee, Kyung Wha J Korean Med Sci Original Article It has been speculated that human leukocyte antigen (HLA) alleles are associated with the outcome of hepatitis B virus (HBV) infection although the data obtained from various populations have shown some inconsistencies. A total of 464 HBV-infected Korean individuals (80 spontaneously recovered [SR] and 384 chronically infected [CI]) were selected to investigate the association of HLA class II alleles with the viral clearance and persistence. Our results showed that: 1) multiple HLA class II alleles and haplotypes were associated with viral clearance (DRB1*1302, DRB1*1502, DQB1*0302, DQB1*0609, and related-haplotypes) and persistence (DRB1*0701, DQB1*0301, and related-haplotypes); 2) DRB1*1302 and DQB1* 0609 were more strongly associated with viral clearance. And the association of DQB1*0609 (p(c)=0.0084; OR, 7.24) with vial clearance was much stronger than previously recognized, DRB1*1302 (p(c)=0.0038; OR, 4.34); and 3) linkage to a specific DPB1 allele in a haplotype strengthened the association with viral clearance, although DPB1 itself was not associated with the outcome. These results indicate the existence of multiple factors controlling viral clearance in the HLA class II gene region. Further extended investigation on the genetic factors related to the outcome of HBV infection will provide valuable insights into the understanding of the mechanisms involved. The Korean Academy of Medical Sciences 2008-10 2008-10-30 /pmc/articles/PMC2579996/ /pubmed/18955791 http://dx.doi.org/10.3346/jkms.2008.23.5.838 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cho, Sung Won
Cheong, Jae Youn
Ju, Young Su
Oh, Do Hoon
Suh, Young Ju
Lee, Kyung Wha
Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title_full Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title_fullStr Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title_full_unstemmed Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title_short Human Leukocyte Antigen Class II Association with Spontaneous Recovery from Hepatitis B Virus Infection in Koreans: Analysis at the Haplotype Level
title_sort human leukocyte antigen class ii association with spontaneous recovery from hepatitis b virus infection in koreans: analysis at the haplotype level
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579996/
https://www.ncbi.nlm.nih.gov/pubmed/18955791
http://dx.doi.org/10.3346/jkms.2008.23.5.838
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