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Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea
The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC)...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580022/ https://www.ncbi.nlm.nih.gov/pubmed/18955782 http://dx.doi.org/10.3346/jkms.2008.23.5.781 |
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author | Cho, Minho Park, Jong Suk Nam, Jisun Kim, Chul Sik Nam, Jae Hyun Kim, Hai Jin Ahn, Chul Woo Cha, Bong Soo Lim, Sung Kil Kim, Kyung Rae Lee, Hyun Chul Huh, Kap Bum |
author_facet | Cho, Minho Park, Jong Suk Nam, Jisun Kim, Chul Sik Nam, Jae Hyun Kim, Hai Jin Ahn, Chul Woo Cha, Bong Soo Lim, Sung Kil Kim, Kyung Rae Lee, Hyun Chul Huh, Kap Bum |
author_sort | Cho, Minho |
collection | PubMed |
description | The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDL-C), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients. |
format | Text |
id | pubmed-2580022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-25800222008-11-07 Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea Cho, Minho Park, Jong Suk Nam, Jisun Kim, Chul Sik Nam, Jae Hyun Kim, Hai Jin Ahn, Chul Woo Cha, Bong Soo Lim, Sung Kil Kim, Kyung Rae Lee, Hyun Chul Huh, Kap Bum J Korean Med Sci Original Article The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDL-C), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients. The Korean Academy of Medical Sciences 2008-10 2008-10-30 /pmc/articles/PMC2580022/ /pubmed/18955782 http://dx.doi.org/10.3346/jkms.2008.23.5.781 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cho, Minho Park, Jong Suk Nam, Jisun Kim, Chul Sik Nam, Jae Hyun Kim, Hai Jin Ahn, Chul Woo Cha, Bong Soo Lim, Sung Kil Kim, Kyung Rae Lee, Hyun Chul Huh, Kap Bum Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title | Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title_full | Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title_fullStr | Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title_full_unstemmed | Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title_short | Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea |
title_sort | association of abdominal obesity with atherosclerosis in type 2 diabetes mellitus (t2dm) in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580022/ https://www.ncbi.nlm.nih.gov/pubmed/18955782 http://dx.doi.org/10.3346/jkms.2008.23.5.781 |
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