APC Activation Restores Functional CD4(+)CD25(+) Regulatory T Cells in NOD Mice that Can Prevent Diabetes Development

BACKGROUND: Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure of NOD APC to properly activate CD4(+)CD25(+) regu...

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Detalles Bibliográficos
Autores principales: Manirarora, Jean N., Kosiewicz, Michele M., Parnell, Sarah A., Alard, Pascale
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580026/
https://www.ncbi.nlm.nih.gov/pubmed/19011680
http://dx.doi.org/10.1371/journal.pone.0003739

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