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Novel suppressors of α-synuclein toxicity identified using yeast

The mechanism by which the Parkinson’s disease-related protein α-synuclein (α-syn) causes neurodegeneration has not been elucidated. To determine the genes that protect cells from α-syn, we used a genetic screen to identify suppressors of the super sensitivity of the yeast Saccharomyces cerevisiae e...

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Detalles Bibliográficos
Autores principales: Liang, Jun, Clark-Dixon, Cheryl, Wang, Shaoxiao, Flower, Todd R., Williams-Hart, Tara, Zweig, Richard, Robinson, Lucy C., Tatchell, Kelly, Witt, Stephan N.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581432/
https://www.ncbi.nlm.nih.gov/pubmed/18772193
http://dx.doi.org/10.1093/hmg/ddn276